Program

Quadruplexes Made in France 

29 novembre 2024, Ecole Polytechnique (Amphi Becquerel)

8h30 Registration Amphi Becquerel

8h45 Opening remarks 

J. L. Mergny (LOB, Ecole Polytechnique / E4H ; Palaiseau) Quadruplexes are everywhere in France...

9h00 Session 1: 4 talks (15 min + 5min questions)

  • J. Dejeu (FEMTO-ST, Besançon) & J. Boissieras (Institut Curie, Orsay), Non selectivity of I-mab for I-motif demonstrated by Bio-Layer Interferometry and Circular dichroism.
  • E. Defrancq (Département de Chimie Moléculaire, Université Grenoble Alpes), Selection and studies of highly selective new G-quadruplex antibodies.
  • M. Ranz (ARNA, Université de Bordeaux), Binding modes and structural dynamics of G4/ligands complexes probed by Hydrogen-Deuterium eXchange coupled to native Mass Spectrometry (HDX/MS).
  • A. Froux (CRAN, Université de Lorraine, Nancy), New Schiff Base Metal Complexes for G-quadruplex binding: from synthesis to anticancer applications.

10h25 Coffee break: poster session

11h00 Session 2: 4 talks (15 min + 5min questions)

  • L. Mouawad (Institut Curie, Orsay), ASC-G4: a website to calculate the Advanced Structural Characteristics of G4.
  • A. Rainot (ITODYS, Paris Cité & STEBICEF, Université de Palerme), In Silico study: Detection of Guanine Quadruplexes via Surface Gated Graphene Transistors.
  • V. Balanikas (LOB, Ecole Polytechnique, Palaiseau), Spectroscopic study of low-energy DNA photoionization using nanosecond transient absorption.
  • R. Veitia (Oncologie moléculaire et pathologies ovariennes, Institut Jacques Monot, Paris Cité), The forkhead DNA-binding domain binds specific G2-rich RNA sequences.

12h20 Lunch Break (Salon d’Honneur) & Poster session

13h30 Session 3: 4 talks (15 min + 5min questions)

  • A. Cammas (Cancer Research Center, Université de Toulouse), RG4s couple translation to therapy-induced autophagy.
  • A. Peynet (GGB, Faculté de Médecine et des Sciences pour la Santé, Brest), Role of non-canonical secondary structures of RNA in the alternative splicing of apoptosis regulatory genes and use as intervention points for cancers resistant to chemotherapies.
  • J. C. Andrau (IGMM, Montpellier), G-quadruplexes are promoter elements involved in nucleosome exclusion and transcriptional pause release.
  • M. Méchali (IGH, Montpellier), G quadruplexes and DNA replication origins.

14h50 Coffee break: Poster session

15h20 Session 4: 5 talks (15 min + 5min questions)

  • G. Giraud (CRCL, Lyon), G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes.
  • L. Ferret (Département de Chimie Moléculaire, Université Grenoble Alpes), Involvement of lysosomes in cancer resistance to transcription inhibitors.
  • K. Mosca (LLB, CEA Saclay), A Novel Workflow for Classifying Nucleic Acid Circular Dichroism Spectra.
  • F. Krikava (Biophysics of nucleic acids, Institute of Biophysics of the Czech Academy of Sciences), Imperfect G-quadruplexes: Structural and thermodynamic studies on dGMP alterations in sequence and environment.
  • N. Da Rocha (Institut Pasteur, Paris), Biochemical and Functional Characterization of SARS-CoV-2 Unique Domain (SUD) in NSP3 / RNA G4 / Protein Complexes and Therapeutic Properties of G4-Ligands Inhibiting their Formation.

17h00 Closing remarks

P. Changenet (LOB, Ecole Polytechnique, Palaiseau)
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