Program

G4 Made in France program

Thursday, November 27

12h30-13h25 : Lunch

Session I : starting at 13h25

Welcome address & practical information (5’)
Jean-Louis Mergny (Ecole Polytechnique / Institut Polytechnique de Paris) Quadruplexes are everywhere!
Eric Defrancq & Natale Noel Scaramozzino (University of Grenoble-Alpes) Selection of novel selective antibodies targeting G-quadruplex DNA
Massimo Trincas (University of Grenoble-Alpes, Department of molecular chemistry) Discovery of novel G-quadruplex binding peptidic derivatives using DNA encoded chemical libraries
Michel Cogné (Univ. & CHU de Rennes) C-rich terminal intronic repeats mirror the G4-rich switch regions and regulate the IGHG gene expression of in human IgG+ B cells

Coffee break

Session II : starting at 16h00

David Monchaud (Université Bourgogne Europe, Dijon) Chemical modulation of G-quadruplex (G4) structures in human cells
Eric Largy (Université de Bordeaux) The Accidental Ligand: A Whirling Foldamer:G4 Complex Dissected with an International Swiss Army Knife
Constanza Avendano Avila (CNRS / ENS Paris-Saclay) Structure and Dynamics of Human Telomeric G-quadruplexes.

17h30-19h Posters / wine & cheese party

Friday, November 28

Session III : starting at 9h00

André Miranda (Univ. Beira Interior, Covilhã, Portugal) Structural insights into a salt-dependent G-quadruplex and its topological modulation by PhenDC3 ligand
Valérie Gabelica (U. Geneva, CH) A mass spectromeetry insight into G-quadruplex structure and biophysics
Vaclav Brazda (Institute of Biophysics, Brno, CZ) Mitochondrial G-quadruplexes evolutionary conservation and a molecular clue to Neanderthal extinction

Coffee break

Session IV : starting at 11h00

Marcel Méchali (IGH, Montpellier) G4 structures are master regulators of initiation of DNA replication
Nezih Karasu (Institut de Génétique de Montpellier) G-quadruplexes involvement in non-canonical genome insulation and genomic instability
Lionel Guittat (LOB, Ecole Polytechnique) Quadruplexes in Archaea

12h30-13h45 : Lunch & Poster session

Session V : starting at 13h45

Caroline Doncarli (Institut Jacques Monod, Paris) Do G-quadruplex motifs confer robust origin activity in restrictive chromosomal environments?
Sabrina Mazzucchi (Sorbonne Université, INSERM, Institut de Myologie, Centre de recherche en Myologie F-75013 Paris, France) Genomic stress drives activation of innate immune pathways during muscle differentiation in a motor neuron disorder
Gabriel Eduardo De Matos Rodrigues (Institut Gustave Roussy, Villejuif) REV3L, the catalytic subunit of Polζ, is required for efficient telomere replication in mammalian cells
Patrizia Alberti (MNHN, Paris) Pentanucleotide guanine-rich WGGGW repeats, including CANVAS AGGGA repeats, form a variety of non-canonical structures
Closing remarks (5’)

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